| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
NPC1 |
| Gene ID: |
4864 |
| Uniprot ID: |
NPC1_HUMAN |
| Immunogen Region: |
23-260 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-260 of human NPC1 (NP_000262.2). |
| Immunogen Sequence: |
QSCVWYGECGIAYGDKRYNC EYSGPPKPLPKDGYDLVQEL CPGFFFGNVSLCCDVRQLQT LKDNLQLPLQFLSRCPSCFY NLLNLFCELTCSPRQSQFLN VTATEDYVDPVTNQTKTNVK ELQYYVGQSFANAMYNACRD VEAPSSNDKALGLLCGKDAD ACNATNWIEYMFNKDNGQAP FTITPVFSDFPVHGMEPMNN ATKGCDESVDEVTAPCSCQD CSIVCGPKPQPPPPPAPW |
| Post Translational Modifications | N-glycosylated. |
| Function | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. |
| Protein Name | Npc Intracellular Cholesterol Transporter 1Niemann-Pick C1 Protein |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Npc Intracellular Cholesterol Transporter 1 antibodyAnti-Niemann-Pick C1 Protein antibodyAnti-NPC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
