Anti-NPAS4 antibody (603-652) (STJ94544)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NPAS4. AA range:603-652
General Information
| Short Description | Rabbit polyclonal anti-Neuronal PAS domain-containing protein 4 (603-652) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NPAS4 |
| Gene ID | 266743 |
| Uniprot ID | NPAS4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NPAS4. AA range:603-652 |
| Immunogen Region | 603-652 |
| Specificity | NPAS4 Polyclonal Antibody detects endogenous levels of NPAS4 protein. |
Additional Info
| Tissue Specificity | Brain. |
| Post Translational Modifications | Ubiquitinated, leading to degradation by the proteosome. |
| Function | Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons. In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits. The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior. Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2. Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1. Can activate the CME (CNS midline enhancer) element. |
| Protein Name | Neuronal Pas Domain-Containing Protein 4Neuronal Pas4Class E Basic Helix-Loop-Helix Protein 79Bhlhe79Hlh-Pas Transcription Factor NxfPas Domain-Containing Protein 10 |
| Database Links | Reactome: R-HSA-9768778Reactome: R-HSA-9768919 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Neuronal Pas Domain-Containing Protein 4 antibodyAnti-Neuronal Pas4 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 79 antibodyAnti-Bhlhe79 antibodyAnti-Hlh-Pas Transcription Factor Nxf antibodyAnti-Pas Domain-Containing Protein 10 antibodyAnti-NPAS4 antibodyAnti-BHLHE79 antibodyAnti-NXF antibodyAnti-PASD10 antibody |
Information sourced from Uniprot.org