• Western Blot of Anti-NOS2 antibody (STJ503604) with Osteoblast cells (A) and cells treated to induce the INOS protein (B). Cell extracts were made with protease inhibitors and 50-60ug protein was resolved on SDS-PAGE for western blotting. Antibody at 1:500 dilution in buffer.

Anti-NOS2 antibody (1064-1114) (STJ503604)

SKU:
STJ503604-100

£441.50
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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NOS2 (1064-1114) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NOS2
Gene ID: 4843
Uniprot ID: NOS2_HUMAN
Immunogen Region: 1064-1114
Specificity: This antibody will detect both iNOS and iNOS2 protein.
Immunogen: Synthetic peptide taken within amino acid region 1064-1114 on human inducible nitric oxide synthase protein.
Tissue Specificity Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes.
Post Translational Modifications Polyubiquitinated.mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8.
Protein Name Nitric Oxide Synthase - Inducible
Hepatocyte Nos
Hep-Nos
Inducible No Synthase
Inducible Nos
Inos
Nos Type Ii
Peptidyl-Cysteine S-Nitrosylase Nos2
Database Links Reactome: R-HSA-1222556
Reactome: R-HSA-392154
Reactome: R-HSA-6785807
Reactome: R-HSA-9033241
Reactome: R-HSA-9636249
Cellular Localisation Cytoplasm
Cytosol
Localizes As Discrete Foci Scattered Throughout The Cytosol And In The Presence Of Spsb1 And Spsb4
Exhibits A More Diffuse Cytosolic Localization
Alternative Antibody Names Anti-Nitric Oxide Synthase - Inducible antibody
Anti-Hepatocyte Nos antibody
Anti-Hep-Nos antibody
Anti-Inducible No Synthase antibody
Anti-Inducible Nos antibody
Anti-Inos antibody
Anti-Nos Type Ii antibody
Anti-Peptidyl-Cysteine S-Nitrosylase Nos2 antibody
Anti-NOS2 antibody
Anti-NOS2A antibody

Information sourced from Uniprot.org

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