Anti-NOP2 antibody (STJA0007573)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NOP2
General Information
| Short Description | Rabbit polyclonal anti-Probable 28S rRNA-C5-methyltransferase for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOP2 |
| Gene ID | 4839 |
| Uniprot ID | NOP2_HUMAN |
| Immunogen | Synthesized peptide derived from human NOP2 |
| Specificity | This antibody detects endogenous levels of NOP2 at Human |
Additional Info
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. |
| Protein Name | 28s RrnaCytosine(4447-C(5-MethyltransferaseNucleolar Protein 1Nucleolar Protein 2 HomologProliferating-Cell Nucleolar Antigen P120Proliferation-Associated Nucleolar Protein P120 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-8869496 |
| Cellular Localisation | NucleusNucleolusLocalizes Predominantly In The Nucleolus And To A Smaller Extent In The Nucleus |
| Alternative Antibody Names | Anti-28s Rrna antibodyAnti-Cytosine(4447-C(5-Methyltransferase antibodyAnti-Nucleolar Protein 1 antibodyAnti-Nucleolar Protein 2 Homolog antibodyAnti-Proliferating-Cell Nucleolar Antigen P120 antibodyAnti-Proliferation-Associated Nucleolar Protein P120 antibodyAnti-NOP2 antibodyAnti-NOL1 antibodyAnti-NSUN1 antibody |
Information sourced from Uniprot.org