| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 3Nucleolar Protein 10Nucleolar Protein Family A Member 3Snornp Protein Nop10 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit 3 antibodyAnti-Nucleolar Protein 10 antibodyAnti-Nucleolar Protein Family A Member 3 antibodyAnti-Snornp Protein Nop10 antibodyAnti-NOP10 antibodyAnti-NOLA3 antibody |
Information sourced from Uniprot.org
