Anti-NOP10 antibody (1-64) (STJ11100207)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NOP10 (1-64) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOP10 |
| Gene ID | 55505 |
| Uniprot ID | NOP10_HUMAN |
| Immunogen Region | 1-64 |
| Immunogen Sequence | MFLQYYLNEQGDRVYTLKKF DPMGQQTCSAHPARFSPDDK YSRHRITIKKRFKVLMTQQP RPVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-64 of human NOP10 (NP_061118.1). |
Additional Info
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 3Nucleolar Protein 10Nucleolar Protein Family A Member 3Snornp Protein Nop10 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit 3 antibodyAnti-Nucleolar Protein 10 antibodyAnti-Nucleolar Protein Family A Member 3 antibodyAnti-Snornp Protein Nop10 antibodyAnti-NOP10 antibodyAnti-NOLA3 antibody |
Information sourced from Uniprot.org