Anti-NMU antibody (125-174) (STJ94433)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NMU. AA range:125-174
General Information
| Short Description | Rabbit polyclonal anti-Neuromedin-U (125-174) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NMU |
| Gene ID | 10874 |
| Uniprot ID | NMU_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NMU. AA range:125-174 |
| Immunogen Region | 125-174 |
| Specificity | Neuromedin-U Polyclonal Antibody detects endogenous levels of Neuromedin-U protein. |
Additional Info
| Tissue Specificity | Expressed throughout the enteric nervous system with highest levels being found in the jejunum. |
| Function | Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. |
| Protein Name | Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36Nurp36 - Neuromedin Precursor-Related Peptide 33Nurp33 - Neuromedin-U-25Nmu-25 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36 antibodyAnti-Nurp36 - Neuromedin Precursor-Related Peptide 33 antibodyAnti-Nurp33 - Neuromedin-U-25 antibodyAnti-Nmu-25 antibodyAnti-NMU antibody |
Information sourced from Uniprot.org