| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
NMRAL1 |
| Gene ID: |
57407 |
| Uniprot ID: |
NMRL1_HUMAN |
| Immunogen Region: |
200-299 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-299 of human NMRAL1 (NP_065728.1). |
| Immunogen Sequence: |
LLKMPEKYVGQNIGLSTCRH TAEEYAALLTKHTRKVVHDA KMTPEDYEKLGFPGARDLAN MFRFYALRPDRDIELTLRLN PKALTLDQWLEQHKGDFNLL |
| Function | Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. |
| Protein Name | Nmra-Like Family Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusUnder Normal Redox Growth Conditions Localizes In The Cytoplasm And Perinuclear RegionNuclear Localization Is Promoted By Increased Intracellular Nitric Oxide And Reduced Nadph/Nadp(+) Ratios |
| Alternative Antibody Names | Anti-Nmra-Like Family Domain-Containing Protein 1 antibodyAnti-NMRAL1 antibodyAnti-HSCARG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
