| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMNAT2 (1-302) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NMNAT2 |
| Gene ID: |
23057 |
| Uniprot ID: |
NMNA2_HUMAN |
| Immunogen Region: |
1-302 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human NMNAT2 (NP_733820.1). |
| Immunogen Sequence: |
MEIQELEEIQACQGLWEVFV TLSERARDYLHKTGRFIVIG GIVSPVHDSYGKQGLVSSRH RLIMCQLAVQNSDWIRVDPW ECYQDTWQTTCSVLEHHRDL MKRVTGCILSNVNTPSMTPV IGQPQNETPQPIYQNSNVAT KPTAAKILGKVGESLSRICC VRPPVERFTFVDENANLGTV MRYEEIELRILLLCGSDLLE SFCIPGLWNEADMEVIVGDF GIVVVPRDAADTDRIMNHS |
| Tissue Specificity | Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. |
| Post Translational Modifications | Degraded in response to injured neurite. Degradation is caused by polyubiquitination by MYCBP2 after recognition by FBXO45. Palmitoylated.palmitoylation is required for membrane association. |
| Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2Nmn/Namn Adenylyltransferase 2Nicotinamide Mononucleotide Adenylyltransferase 2Nmn Adenylyltransferase 2Nicotinate-Nucleotide Adenylyltransferase 2Namn Adenylyltransferase 2 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic Vesicle MembraneCytoplasmCell ProjectionAxonDelivered To Axons With Golgi-Derived Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn/Namn Adenylyltransferase 2 antibodyAnti-Nicotinamide Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn Adenylyltransferase 2 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 2 antibodyAnti-Namn Adenylyltransferase 2 antibodyAnti-NMNAT2 antibodyAnti-C1orf15 antibodyAnti-KIAA0479 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
