| Tissue Specificity | Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. |
| Post Translational Modifications | Degraded in response to injured neurite. Degradation is caused by polyubiquitination by MYCBP2 after recognition by FBXO45. Palmitoylated.palmitoylation is required for membrane association. |
| Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2Nmn/Namn Adenylyltransferase 2Nicotinamide Mononucleotide Adenylyltransferase 2Nmn Adenylyltransferase 2Nicotinate-Nucleotide Adenylyltransferase 2Namn Adenylyltransferase 2 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic Vesicle MembraneCytoplasmCell ProjectionAxonDelivered To Axons With Golgi-Derived Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn/Namn Adenylyltransferase 2 antibodyAnti-Nicotinamide Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn Adenylyltransferase 2 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 2 antibodyAnti-Namn Adenylyltransferase 2 antibodyAnti-NMNAT2 antibodyAnti-C1orf15 antibodyAnti-KIAA0479 antibody |
Information sourced from Uniprot.org
