• Western blot of 10 µg of HEK 293 cells showing specific immunolabeling of the ~120 kDa NR1 subunit of the NMDA receptor containing the C2 splice variant insert (lane 2). 1) HEK cells without NR1 expression; 2) NR1 subunit containing only the C2 Insert; 3) NR1 subunit containing the C1 and C2 NA insert; 4) NR1 subunit containing the N1 and C2 NA insert.

Anti-NMDAR1 C2 antibody (STJA0003707)

SKU:
STJA0003707-25

£454.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NMDAR1 C2 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilized
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Grin1
Gene ID: 24408
Uniprot ID: NMDZ1_RAT
Immunogen: Synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2 splice variant insert conjugated to KLH.
Tissue Specificity Detected throughout the brain, in brain cortex, cerebellum, thalamus and olfactory bulb.
Post Translational Modifications NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
Function Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. Forms excitatory glycinergic receptor complexes with GluN3 alone which are activated by glycine binding to the GluN1 and GluN3 subunits.
Protein Name Glutamate Receptor Ionotropic - Nmda 1
Glun1
Glutamate Nmda Receptor Subunit Zeta-1
N-Methyl-D-Aspartate Receptor Subunit Nr1
Nmd-R1
Database Links Reactome: R-RNO-3928662
Reactome: -RNO-438066
Reactome: -RNO-5673001
Reactome: -RNO-8849932
Reactome: -RNO-9609736
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Synaptic Cell Membrane
Postsynaptic Density Membrane
Synaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b Subunit
Association With Grin3a Occurs In The Endoplasmic Reticulum
Alternative Antibody Names Anti-Glutamate Receptor Ionotropic - Nmda 1 antibody
Anti-Glun1 antibody
Anti-Glutamate Nmda Receptor Subunit Zeta-1 antibody
Anti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibody
Anti-Nmd-R1 antibody
Anti-Grin1 antibody
Anti-Nmdar1 antibody

Information sourced from Uniprot.org

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