Anti-NMDA receptor 1/GRIN1 antibody (Internal) (STJ70967)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NMDA receptor 1/GRIN1 (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | Pep-ELISA/IF |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.IF: Strong expression of the protein seen in the membrane and cytoplasm of MCF7 and NIH3T3 cells. Recommended concentration: 10ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIN1 |
| Gene ID | 2902 |
| Uniprot ID | NMDZ1_HUMAN |
| Accession Number | NP_000823.4; NP_067544.1; NP_015566.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TQERVNNSNKKE |
| Specificity | This antibody is expected to recognise all three reported isoforms (NP_000823.4; NP_067544.1; NP_015566.1). |
Additional Info
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1Glun1Glutamate Nmda Receptor Subunit Zeta-1N-Methyl-D-Aspartate Receptor Subunit Nr1Nmd-R1Hnr1 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneSynaptic Cell MembraneSynaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b SubunitAssociation With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 1 antibodyAnti-Glun1 antibodyAnti-Glutamate Nmda Receptor Subunit Zeta-1 antibodyAnti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibodyAnti-Nmd-R1 antibodyAnti-Hnr1 antibodyAnti-GRIN1 antibodyAnti-NMDAR1 antibody |
Information sourced from Uniprot.org