Anti-NLRX1/NOD9 antibody (Internal) (STJ72177)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NLRX1/NOD9 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 100kDa band observed in Human Breast cancer lysates (calculated MW of 108kDa according to NP_078894.2 and 102kDa according to NP_733840.1). Recommended concentration: 1-3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NLRX1 |
| Gene ID | 79671 |
| Uniprot ID | NLRX1_HUMAN |
| Accession Number | NP_078894.2; NP_733840.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | NFSGETLDSTDPSN |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_078894.2; NP_733840.1). |
Additional Info
| Function | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases. |
| Protein Name | Nlr Family Member X1Caterpiller Protein 11.3Clr11.3Nucleotide-Binding Oligomerization Domain Protein 5Nucleotide-Binding Oligomerization Domain Protein 9 |
| Database Links | Reactome: R-HSA-168928Reactome: R-HSA-936440Reactome: R-HSA-9758274 |
| Cellular Localisation | Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Nlr Family Member X1 antibodyAnti-Caterpiller Protein 11.3 antibodyAnti-Clr11.3 antibodyAnti-Nucleotide-Binding Oligomerization Domain Protein 5 antibodyAnti-Nucleotide-Binding Oligomerization Domain Protein 9 antibodyAnti-NLRX1 antibodyAnti-NOD5 antibodyAnti-NOD9 antibody |
Information sourced from Uniprot.org