• Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • Western blot analysis of HEPG2 Hela cells using NLRX1 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000

Anti-NLRX1 antibody (581-630 aa) (STJ98633)

SKU:
STJ98633

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NLR family member X1 (581-630 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NLRX1
Gene ID: 79671
Uniprot ID: NLRX1_HUMAN
Immunogen Region: 581-630 aa
Specificity: NLRX1 Polyclonal Antibody detects endogenous levels of NLRX1
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NLRX1 at the amino acid range 581-630
Function Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases.
Protein Name Nlr Family Member X1
Caterpiller Protein 11.3
Clr11.3
Nucleotide-Binding Oligomerization Domain Protein 5
Nucleotide-Binding Oligomerization Domain Protein 9
Database Links Reactome: R-HSA-168928
Reactome: R-HSA-936440
Reactome: R-HSA-9758274
Cellular Localisation Mitochondrion Outer Membrane
Alternative Antibody Names Anti-Nlr Family Member X1 antibody
Anti-Caterpiller Protein 11.3 antibody
Anti-Clr11.3 antibody
Anti-Nucleotide-Binding Oligomerization Domain Protein 5 antibody
Anti-Nucleotide-Binding Oligomerization Domain Protein 9 antibody
Anti-NLRX1 antibody
Anti-NOD5 antibody
Anti-NOD9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance