| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | NKD2 |
| Gene ID: | 85409 |
| Uniprot ID: | NKD2_HUMAN |
| Immunogen Region: | 30-110 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-110 of human NKD2 (NP_001258011). |
| Immunogen Sequence: | ASGRKGAEEAERRARDKQEL PNGDPKEGPFREDQCPLQVA LPAEKAEGREHPGQLLSADD GERAANREGPRGPGGQRLNI D |
| Tissue Specificity | Expressed in kidney, lung, pancreas and spleen. |
| Post Translational Modifications | Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25. |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. |
| Protein Name | Protein Naked Cuticle Homolog 2Naked-2Hnkd2 |
| Cellular Localisation | Cell MembraneCytoplasmCytoplasmic Vesicle |
| Alternative Antibody Names | Anti-Protein Naked Cuticle Homolog 2 antibodyAnti-Naked-2 antibodyAnti-Hnkd2 antibodyAnti-NKD2 antibody |
Information sourced from Uniprot.org