| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-NF-kappa-B inhibitor epsilon (131-180 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NFKBIE |
| Gene ID: | 4794 |
| Uniprot ID: | IKBE_HUMAN |
| Immunogen Region: | 131-180 aa |
| Specificity: | I Kappa B-Epsilon Polyclonal Antibody detects endogenous levels of I Kappa B-Epsilon protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human IkappaB-epsilon at the amino acid range 131-180 |
| Post Translational Modifications | Serine phosphorylated.followed by proteasome-dependent degradation. |
| Function | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development. |
| Protein Name | Nf-Kappa-B Inhibitor EpsilonNf-Kappa-BieI-Kappa-B-EpsilonIkb-EIkb-EpsilonIkappabepsilon |
| Database Links | Reactome: R-HSA-1169091 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Epsilon antibodyAnti-Nf-Kappa-Bie antibodyAnti-I-Kappa-B-Epsilon antibodyAnti-Ikb-E antibodyAnti-Ikb-Epsilon antibodyAnti-Ikappabepsilon antibodyAnti-NFKBIE antibodyAnti-IKBE antibody |
Information sourced from Uniprot.org
