| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NF-kappa-B inhibitor beta (4-53 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NFKBIB |
| Gene ID: |
4793 |
| Uniprot ID: |
IKBB_HUMAN |
| Immunogen Region: |
4-53 aa |
| Specificity: |
I Kappa B-Beta Polyclonal Antibody detects endogenous levels of I Kappa B-Beta protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human IkappaB-beta at the amino acid range 4-53 |
| Post Translational Modifications | Phosphorylated by RPS6KA1.followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Protein Name | Nf-Kappa-B Inhibitor BetaNf-Kappa-BibI-Kappa-B-BetaIkb-BIkb-BetaIkappabbetaThyroid Receptor-Interacting Protein 9Tr-Interacting Protein 9Trip-9 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-445989Reactome: R-HSA-933542 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Beta antibodyAnti-Nf-Kappa-Bib antibodyAnti-I-Kappa-B-Beta antibodyAnti-Ikb-B antibodyAnti-Ikb-Beta antibodyAnti-Ikappabbeta antibodyAnti-Thyroid Receptor-Interacting Protein 9 antibodyAnti-Tr-Interacting Protein 9 antibodyAnti-Trip-9 antibodyAnti-NFKBIB antibodyAnti-IKBB antibodyAnti-TRIP9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
