Anti-NFATC2IP antibody (151-200) (STJ94447)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NFATC2IP. AA range:151-200
General Information
| Short Description | Rabbit polyclonal anti-NFATC2-interacting protein (151-200) for use in WB and IHC in Human, Rat, Mouse and Fish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse/Fish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NFATC2IP |
| Gene ID | 84901 |
| Uniprot ID | NF2IP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NFATC2IP. AA range:151-200 |
| Immunogen Region | 151-200 |
| Specificity | NFATc2IP Polyclonal Antibody detects endogenous levels of NFATc2IP protein. |
Additional Info
| Post Translational Modifications | Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. |
| Function | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter.this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. |
| Protein Name | Nfatc2-Interacting Protein45 Kda Nf-At-Interacting Protein45 Kda Nfat-Interacting ProteinNuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmTraf1 Is Associated With A Fraction Of Nfatc2ip In The Cytoplasm And Prevents Its Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Nfatc2-Interacting Protein antibodyAnti-45 Kda Nf-At-Interacting Protein antibodyAnti-45 Kda Nfat-Interacting Protein antibodyAnti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 2-Interacting Protein antibodyAnti-NFATC2IP antibodyAnti-NIP45 antibody |
Information sourced from Uniprot.org