Anti-Neuropeptide RFRP-3 antibody (RFRP-1) (STJA0040726)
SPECIFICATIONS
ClonalityPolyclonal
HostGuinea Pig
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (VPNLPQRF) corresponding to the amino acids 124-131 from human Neuropeptide VF. Neuropeptide VF is the precursor of the neuropeptides NPSF (RFRP-1) , RFRP-2 and RFRP-3. The synthetic peptide was conjugated to a carrier protein KLH
General Information
| Short Description | Guinea Pig polyclonal anti-Neuropeptide RFRP-3 (RFRP-1) for use in IHC-F in Human, Rat and Sheep samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F |
| Host | Guinea Pig |
| Reactivity | Human/Rat/Sheep |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | IHC 1.4305555555555556 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 50 ยตL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8ยฐC or lower. After reconstitution, divide into aliquots and store at-20ยฐC, or low |
Target Information
| Gene Symbol | NPVF |
| Gene ID | 64111 |
| Uniprot ID | NPVF_HUMAN |
| Immunogen | A synthetic peptide (VPNLPQRF) corresponding to the amino acids 124-131 from human Neuropeptide VF. Neuropeptide VF is the precursor of the neuropeptides NPSF (RFRP-1) , RFRP-2 and RFRP-3. The synthetic peptide was conjugated to a carrier protein KLH |
| Immunogen Region | RFRP-1 |
| Immunogen Sequence | Human |
| Specificity | Specificity was demonstrated by immunohistochemistry. This antibody is known to react with rat and sheep. |
Additional Info
| Tissue Specificity | Isoform 1: Specifically expressed in the retina. Neuropeptide RFRP-1: Detected in the hypothalamus. Neuropeptide NPVF: Detected in the hypothalamus. |
| Function | Neuropeptide RFRP-1: Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion. Induces secretion of prolactin. Neuropeptide NPVF: Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia. Neuropeptide RFRP-2: Shows no inhibitory activity of forskolin-induced production of cAMP. |
| Protein Name | Pro-Fmrfamide-Related Neuropeptide Vf Cleaved Into - Neuropeptide Npsf - Neuropeptide Rfrp-1 - Neuropeptide Rfrp-2 - Neuropeptide NpvfNeuropeptide Rfrp-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Fmrfamide-Related Neuropeptide Vf Cleaved Into - Neuropeptide Npsf - Neuropeptide Rfrp-1 - Neuropeptide Rfrp-2 - Neuropeptide Npvf antibodyAnti-Neuropeptide Rfrp-3 antibodyAnti-NPVF antibodyAnti-C7orf9 antibodyAnti-RFRP antibody |
Information sourced from Uniprot.org