Anti-Neuroligin 1 antibody (Internal) (STJ70748)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Neuroligin 1 (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | Pep-ELISA/IF |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments gave an approx 150kDa band in Human Brain lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NLGN1 |
| Gene ID | 22871 |
| Uniprot ID | NLGN1_HUMAN |
| Accession Number | NP_055747.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TAKQDDPKQQ |
Additional Info
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development. |
| Protein Name | Neuroligin-1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPostsynaptic DensitySynaptic CleftSynaptic Cell MembraneEnriched In Synaptic Plasma Membranes And Clustered In Synaptic Clefts And Postsynaptic DensitiesColocalized With Dlg4/Psd-95 And Grin1/Nmdar1 |
| Alternative Antibody Names | Anti-Neuroligin-1 antibodyAnti-NLGN1 antibodyAnti-KIAA1070 antibody |
Information sourced from Uniprot.org