| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NEUROD1 (1-356) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEUROD1 |
| Gene ID: |
4760 |
| Uniprot ID: |
NDF1_HUMAN |
| Immunogen Region: |
1-356 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-356 of human NEUROD1 (NP_002491.2). |
| Immunogen Sequence: |
MTKSYSESGLMGEPQPQGPP SWTDECLSSQDEEHEADKKE DDLEAMNAEEDSLRNGGEEE DEDEDLEEEEEEEEEDDDQK PKRRGPKKKKMTKARLERFK LRRMKANARERNRMHGLNAA LDNLRKVVPCYSKTQKLSKI ETLRLAKNYIWALSEILRSG KSPDLVSFVQTLCKGLSQPT TNLVAGCLQLNPRTFLPEQN QDMPPHLPTASASFPVHPYS YQSPGLPSPPYGTMDSSHV |
| Post Translational Modifications | Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation.which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335.which promotes dendritic growth. Phosphorylated by MAPK1.phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells. |
| Function | Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. |
| Protein Name | Neurogenic Differentiation Factor 1NeurodNeurod1Class A Basic Helix-Loop-Helix Protein 3Bhlha3 |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-210746 |
| Cellular Localisation | CytoplasmNucleusIn Pancreatic Islet CellsShuttles To The Nucleus In Response To Glucose StimulationColocalizes With Nr0b2 In The Nucleus |
| Alternative Antibody Names | Anti-Neurogenic Differentiation Factor 1 antibodyAnti-Neurod antibodyAnti-Neurod1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 3 antibodyAnti-Bhlha3 antibodyAnti-NEUROD1 antibodyAnti-BHLHA3 antibodyAnti-NEUROD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
