| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Neuralized-like protein 2 (99-148) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEURL2 |
| Gene ID: | 140825 |
| Uniprot ID: | NEUL2_HUMAN |
| Immunogen Region: | 99-148 |
| Specificity: | Neuralized-2 Polyclonal Antibody detects endogenous levels of Neuralized-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NEURL2. AA range:99-148 |
| Tissue Specificity | Expressed specifically in skeletal and cardiac muscles. |
| Function | Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. |
| Protein Name | Neuralized-Like Protein 2 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Neuralized-Like Protein 2 antibodyAnti-NEURL2 antibodyAnti-C20orf163 antibody |
Information sourced from Uniprot.org