| Tissue Specificity | Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. |
| Post Translational Modifications | N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| Protein Name | Sialidase-1Acetylneuraminyl HydrolaseG9 SialidaseLysosomal SialidaseN-Acetyl-Alpha-Neuraminidase 1 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome MembranePeripheral Membrane ProteinLumenal SideLysosome LumenCell MembraneCytoplasmic VesicleLysosomeLocalized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal LumenBut Also On The Plasma Membrane And In Intracellular Vesicles |
| Alternative Antibody Names | Anti-Sialidase-1 antibodyAnti-Acetylneuraminyl Hydrolase antibodyAnti-G9 Sialidase antibodyAnti-Lysosomal Sialidase antibodyAnti-N-Acetyl-Alpha-Neuraminidase 1 antibodyAnti-NEU1 antibodyAnti-NANH antibody |
Information sourced from Uniprot.org
