| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Sialidase-1 (139-189) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEU1 |
| Gene ID: | 4758 |
| Uniprot ID: | NEUR1_HUMAN |
| Immunogen Region: | 139-189 |
| Specificity: | This antibody detects endogenous levels of human NEUR1 |
| Immunogen: | Synthesized peptide derived from human NEUR1 AA range: 139-189 |
| Post Translational Modifications | N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| Protein Name | Sialidase-1 Acetylneuraminyl Hydrolase G9 Sialidase Lysosomal Sialidase N-Acetyl-Alpha-Neuraminidase 1 |
| Database Links | Reactome: R-HSA-4085001 Reactome: R-HSA-4341670 Reactome: R-HSA-6798695 Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome Membrane Peripheral Membrane Protein Lumenal Side Lysosome Lumen Cell Membrane Cytoplasmic Vesicle Lysosome Localized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal Lumen But Also On The Plasma Membrane And In Intracellular Vesicles |
| Alternative Antibody Names | Anti-Sialidase-1 antibody Anti-Acetylneuraminyl Hydrolase antibody Anti-G9 Sialidase antibody Anti-Lysosomal Sialidase antibody Anti-N-Acetyl-Alpha-Neuraminidase 1 antibody Anti-NEU1 antibody Anti-NANH antibody |
Information sourced from Uniprot.org