| Host: | Chicken |
| Applications: | IHC/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Chicken polyclonal anti-Netrin-1 for use in IHC and ICC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgY |
| Formulation: | Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Purification: | Affinity-Purified IgY |
| Concentration: | 100 µg/mL |
| Dilution Range: | WB Not RecommendedWB Brain Not RecommendedIHC 1:1000-1:2000ICC 1:1000-1:2000 |
| Storage Instruction: | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
| Gene Symbol: | NTN1 |
| Gene ID: | 9423 |
| Uniprot ID: | NET1_HUMAN |
| Immunogen: | Synthetic peptide |
| Immunogen Sequence: | Human, Mouse, Rat |
| Function | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. |
| Protein Name | Netrin-1Epididymis Tissue Protein Li 131p |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | SecretedCytoplasmMainly Secreted |
| Alternative Antibody Names | Anti-Netrin-1 antibodyAnti-Epididymis Tissue Protein Li 131p antibodyAnti-NTN1 antibodyAnti-NTN1L antibody |
Information sourced from Uniprot.org
