| Host: | Goat |
| Applications: | Pep-ELISA/IF |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Netrin 1 (C-Term) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.IF: Strong expression of the protein seen in the membrane and cytoplasm of U2OS cells. Recommended concentration: 10µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NTN1 |
| Gene ID: | 9423 |
| Uniprot ID: | NET1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_004813.2 |
| Immunogen Sequence: | KFQQREKKGKCKKA |
| Function | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. |
| Protein Name | Netrin-1Epididymis Tissue Protein Li 131p |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | SecretedCytoplasmMainly Secreted |
| Alternative Antibody Names | Anti-Netrin-1 antibodyAnti-Epididymis Tissue Protein Li 131p antibodyAnti-NTN1 antibodyAnti-NTN1L antibody |
Information sourced from Uniprot.org