| Tissue Specificity | Expressed in aortic endothelial cells (at protein level). |
| Post Translational Modifications | The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. |
| Protein Name | Nesprin-3Kash Domain-Containing Protein 3Kash3Nuclear Envelope Spectrin Repeat Protein 3 |
| Database Links | |
| Cellular Localisation | Nucleus Outer MembraneSingle-Pass Type Iv Membrane ProteinNucleus EnvelopeRough Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Nesprin-3 antibodyAnti-Kash Domain-Containing Protein 3 antibodyAnti-Kash3 antibodyAnti-Nuclear Envelope Spectrin Repeat Protein 3 antibodyAnti-SYNE3 antibodyAnti-C14orf139 antibodyAnti-C14orf49 antibodyAnti-LINC00341 antibody |
Information sourced from Uniprot.org
