| Short Description : | Rabbit polyclonal NELL2 (22-300) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NELL2 |
| Gene ID: | 4753 |
| Uniprot ID: | NELL2_HUMAN |
| Immunogen Region: | 22-300 |
| Immunogen Sequence: | LGVDPSLQIDVLTELELGES TTGVRQVPGLHNGTKAFLFQ DTPRSIKASTATAEQFFQKL RNKHEFTILVTLKQTHLNSG VILSIHHLDHRYLELESSGH RNEVRLHYRSGSHRPHTEVF PYILADDKWHKLSLAISASH LILHIDCNKIYERVVEKPST DLPLGTTFWLGQRNNAHGYF KGIMQDVQLLVMPQGFIAQC PDLNRTCPTCNDFHGLVQKI MELQDILAKTSAKLSRAEQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-300 of human NELL2 (NP_006150.1). |
| Function | Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway. Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline. Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty. Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. |
| Protein Name | Protein Kinase C-Binding Protein Nell2Nel-Like Protein 2Nel-Related Protein 2 |
| Database Links | Reactome: R-HSA-428542 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protein Kinase C-Binding Protein Nell2 antibodyAnti-Nel-Like Protein 2 antibodyAnti-Nel-Related Protein 2 antibodyAnti-NELL2 antibodyAnti-NRP2 antibody |
Information sourced from Uniprot.org
