| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-GRIM19 (1-144) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S0MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NDUFA13 |
| Gene ID: |
51079 |
| Uniprot ID: |
NDUAD_HUMAN |
| Immunogen Region: |
1-144 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human NDUFA13/GRIM19 (Q9P0J0) (NP_057049.5) |
| Immunogen Sequence: |
MAASKVKQDMPPPGGYGPID YKRNLPRRGLSGYSMLAIGI GTLIYGHWSIMKWNRERRRL QIEDFEARIALLPLLQAETD RRTLQMLRENLEEEAIIMKD VPDWKVGESVFHTTRWVPPL IGELYGLRTTEEALHASHGF MWYT |
| Tissue Specificity | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. |
| Protein Name | Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13Cell Death Regulatory Protein Grim-19Complex I-B16.6Ci-B16.6Gene Associated With Retinoic And Interferon-Induced Mortality 19 ProteinGrim-19Gene Associated With Retinoic And Ifn-Induced Mortality 19 ProteinNadh-Ubiquinone Oxidoreductase B16.6 Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMatrix SideNucleusLocalizes Mainly In The MitochondrionMay Be Translocated Into The Nucleus Upon Ifn/Ra Treatment |
| Alternative Antibody Names | Anti-Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13 antibodyAnti-Cell Death Regulatory Protein Grim-19 antibodyAnti-Complex I-B16.6 antibodyAnti-Ci-B16.6 antibodyAnti-Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein antibodyAnti-Grim-19 antibodyAnti-Gene Associated With Retinoic And Ifn-Induced Mortality 19 Protein antibodyAnti-Nadh-Ubiquinone Oxidoreductase B16.6 Subunit antibodyAnti-NDUFA13 antibodyAnti-GRIM19 antibodyAnti-CDA016 antibodyAnti-CGI-39 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and NDUFA13/GRIM19 knockout (KO) HeLa cells, using [KO Validated] NDUFA13/GRIM19 Rabbit polyclonal antibody (STJ11100044) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89116/357568/STJ11100044_1__64463.1713121695.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and NDUFA13/GRIM19 knockout (KO) HeLa cells, using [KO Validated] NDUFA13/GRIM19 Rabbit polyclonal antibody (STJ11100044) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
