Anti-NDRG2 antibody (10-90) (STJ94369)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from NDRG2. at AA range: 10-90
General Information
| Short Description | Rabbit polyclonal anti-Protein NDRG2 (10-90) for use in IHC, IF, WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NDRG2 |
| Gene ID | 57447 |
| Uniprot ID | NDRG2_HUMAN |
| Immunogen | Synthesized peptide derived from NDRG2. at AA range: 10-90 |
| Immunogen Region | 10-90 |
| Specificity | NDRG2 Polyclonal Antibody detects endogenous levels of NDRG2 protein. |
Additional Info
| Tissue Specificity | Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues.absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). |
| Function | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. |
| Protein Name | Protein Ndrg2N-Myc Downstream-Regulated Gene 2 ProteinProtein Syld709613 |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionGrowth ConeIn NeuronsSeems To Concentrate At Axonal Growth ConePerinuclear In Neurons |
| Alternative Antibody Names | Anti-Protein Ndrg2 antibodyAnti-N-Myc Downstream-Regulated Gene 2 Protein antibodyAnti-Protein Syld709613 antibodyAnti-NDRG2 antibodyAnti-KIAA1248 antibodyAnti-SYLD antibody |
Information sourced from Uniprot.org