| Short Description : | Rabbit polyclonal anti-Norrin (40-120 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NDP |
| Gene ID: | 4693 |
| Uniprot ID: | NDP_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 40-120 |
| Immunogen Region: | 40-120 aa |
| Specificity: | NDP Polyclonal Antibody detects endogenous levels of protein. |
| Function | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Protein Name | NorrinNorrie Disease ProteinX-Linked Exudative Vitreoretinopathy 2 Protein |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Norrin antibodyAnti-Norrie Disease Protein antibodyAnti-X-Linked Exudative Vitreoretinopathy 2 Protein antibodyAnti-NDP antibodyAnti-EVR2 antibody |
Information sourced from Uniprot.org
