| Tissue Specificity | Detected primarily in heart and at lower levels in brain. Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. |
| Function | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. |
| Protein Name | Sodium/Calcium Exchanger 1Na(+/Ca(2+-Exchange Protein 1Solute Carrier Family 8 Member 1 |
| Database Links | Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-5578775 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 1 antibodyAnti-Na(+/Ca(2+-Exchange Protein 1 antibodyAnti-Solute Carrier Family 8 Member 1 antibodyAnti-SLC8A1 antibodyAnti-CNC antibodyAnti-NCX1 antibody |
Information sourced from Uniprot.org
