| Host: | Goat |
| Applications: | Pep-ELISA/IF |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-NCOR1 (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. IF: Strong expression of the protein seen in the nuclei of Jurkat cells. Recommended concentration: 10µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NCOR1 |
| Gene ID: | 9611 |
| Uniprot ID: | NCOR1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_006302.2 |
| Immunogen Sequence: | SYDNIKNAREGTRSP |
| Function | Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. |
| Protein Name | Nuclear Receptor Corepressor 1 N-Cor N-Cor1 |
| Database Links | Reactome: R-HSA-1251985 Reactome: R-HSA-1368071 Reactome: R-HSA-1989781 Reactome: R-HSA-2122947 Reactome: R-HSA-2151201 Reactome: R-HSA-2173795 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3214815 Reactome: R-HSA-350054 Reactome: R-HSA-381340 Reactome: R-HSA-383280 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-5617472 Reactome: R-HSA-9022537 Reactome: R-HSA-9022692 Reactome: R-HSA-9029569 Reactome: R-HSA-9609690 Reactome: R-HSA-9623433 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 1 antibody Anti-N-Cor antibody Anti-N-Cor1 antibody Anti-NCOR1 antibody Anti-KIAA1047 antibody |
Information sourced from Uniprot.org