Anti-NCOR1 antibody (1-200) (STJ29126)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NCOR1 (1-200) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCOR1 |
| Gene ID | 9611 |
| Uniprot ID | NCOR1_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MSSSGYPPNQGAFSTEQSRY PPHSVQYTFPNTRHQQEFAV PDYRSSHLEVSQASQLLQQQ QQQQLRRRPSLLSEFHPGSD RPQERRTSYEPFHPGPSPVD HDSLESKRPRLEQVSDSHFQ RVSAAVLPLVHPLPEGLRAS ADAKKDPAFGGKHEAPSSPI SGQPCGDDQNASPSKLSKEE LIQSMDRVDREIAKVEQQIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NCOR1 (NP_006302.2). |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. |
| Protein Name | Nuclear Receptor Corepressor 1N-CorN-Cor1 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-1368071Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5617472Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9623433Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 1 antibodyAnti-N-Cor antibodyAnti-N-Cor1 antibodyAnti-NCOR1 antibodyAnti-KIAA1047 antibody |
Information sourced from Uniprot.org