| Post Translational Modifications | Phosphorylated by PRKDC. Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Protein Name | Nuclear Receptor Coactivator 6Activating Signal Cointegrator 2Asc-2Amplified In Breast Cancer Protein 3Cancer-Amplified Transcriptional Coactivator Asc-2Nuclear Receptor Coactivator Rap250Nrc Rap250Nuclear Receptor-Activating Protein - 250 KdaPeroxisome Proliferator-Activated Receptor-Interacting ProteinPpar-Interacting ProteinPripThyroid Hormone Receptor-Binding Protein |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5617472Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 6 antibodyAnti-Activating Signal Cointegrator 2 antibodyAnti-Asc-2 antibodyAnti-Amplified In Breast Cancer Protein 3 antibodyAnti-Cancer-Amplified Transcriptional Coactivator Asc-2 antibodyAnti-Nuclear Receptor Coactivator Rap250 antibodyAnti-Nrc Rap250 antibodyAnti-Nuclear Receptor-Activating Protein - 250 Kda antibodyAnti-Peroxisome Proliferator-Activated Receptor-Interacting Protein antibodyAnti-Ppar-Interacting Protein antibodyAnti-Prip antibodyAnti-Thyroid Hormone Receptor-Binding Protein antibodyAnti-NCOA6 antibodyAnti-AIB3 antibodyAnti-KIAA0181 antibodyAnti-RAP250 antibodyAnti-TRBP antibody |
Information sourced from Uniprot.org
