| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Nck-associated protein 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCKAP1 |
| Gene ID: | 10787 |
| Uniprot ID: | NCKP1_HUMAN |
| Specificity: | This antibody detects endogenous levels of NCKAP1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human NCKAP1 |
| Function | Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. |
| Protein Name | Nck-Associated Protein 1 Nap 1 Membrane-Associated Protein Hem-2 P125nap1 |
| Database Links | Reactome: R-HSA-2029482 Reactome: R-HSA-4420097 Reactome: R-HSA-5663213 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013423 Reactome: R-HSA-9664422 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Cytoplasmic Side Cell Projection Lamellipodium Membrane At The Interface Between The Lamellipodial Actin Meshwork And The Membrane |
| Alternative Antibody Names | Anti-Nck-Associated Protein 1 antibody Anti-Nap 1 antibody Anti-Membrane-Associated Protein Hem-2 antibody Anti-P125nap1 antibody Anti-NCKAP1 antibody Anti-HEM2 antibody Anti-KIAA0587 antibody Anti-NAP1 antibody |
Information sourced from Uniprot.org