| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Condensin complex subunit 3 (951-1000 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCAPG |
| Gene ID: | 64151 |
| Uniprot ID: | CND3_HUMAN |
| Immunogen Region: | 951-1000 aa |
| Specificity: | hCAP-G Polyclonal Antibody detects endogenous levels of hCAP-G protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human NCAPG at the amino acid range 951-1000 |
| Post Translational Modifications | Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation. |
| Function | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
| Protein Name | Condensin Complex Subunit 3 Chromosome-Associated Protein G Condensin Subunit Cap-G Hcap-G Melanoma Antigen Ny-Mel-3 Non-Smc Condensin I Complex Subunit G Xcap-G Homolog |
| Database Links | Reactome: R-HSA-2514853 |
| Cellular Localisation | Nucleus Cytoplasm Chromosome In Interphase Cells The Majority Of The Condensin Complex Is Found In The Cytoplasm While A Minority Of The Complex Is Associated With Chromatin A Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase Cells During Mitosis Most Of The Condensin Complex Is Associated With The Chromatin At The Onset Of Prophase The Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1 Leading To Condensin's Association With Chromosome Arms And To Chromosome Condensation Dissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Condensin Complex Subunit 3 antibody Anti-Chromosome-Associated Protein G antibody Anti-Condensin Subunit Cap-G antibody Anti-Hcap-G antibody Anti-Melanoma Antigen Ny-Mel-3 antibody Anti-Non-Smc Condensin I Complex Subunit G antibody Anti-Xcap-G Homolog antibody Anti-NCAPG antibody Anti-CAPG antibody Anti-NYMEL3 antibody |
Information sourced from Uniprot.org