• Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using NBR1 Mouse mAb diluted at 1:200.
  • Immunohistochemical analysis of paraffin-embedded Human-liver tissue. 1, NBR1 Mouse monoclonal antibody (7C3) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
  • Immunohistochemical analysis of paraffin-embedded Rat-lung tissue. 1, NBR1 Mouse monoclonal antibody (7C3) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
  • Immunofluorescence analysis of rat-spleen tissue. 1, NBR1 Mouse monoclonal antibody (7C3) (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).3, Picture B: DAPI (blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

Anti-NBR1 antibody (STJ98902)

SKU:
STJ98902

£46.00 - £226.00
Current Stock:
Host: Mouse
Applications: IF/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Next to BRCA1 gene 1 protein is suitable for use in Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:50-200
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NBR1
Gene ID: 4077
Uniprot ID: NBR1_HUMAN
Specificity: The antibody detects endogenous NBR1 protein
Immunogen: Recombinant Protein of NBR1
Function Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion.
Protein Name Next To Brca1 Gene 1 Protein
Cell Migration-Inducing Gene 19 Protein
Membrane Component Chromosome 17 Surface Marker 2
Neighbor Of Brca1 Gene 1 Protein
Protein 1a1-3b
Database Links Reactome: R-HSA-9664873
Cellular Localisation Cytoplasm
Cytoplasmic Vesicle
Autophagosome
Lysosome
Myofibril
Sarcomere
M Line
In Cardiac Muscles Localizes To The Sarcomeric M Line
Is Targeted To Lysosomes For Degradation
Alternative Antibody Names Anti-Next To Brca1 Gene 1 Protein antibody
Anti-Cell Migration-Inducing Gene 19 Protein antibody
Anti-Membrane Component Chromosome 17 Surface Marker 2 antibody
Anti-Neighbor Of Brca1 Gene 1 Protein antibody
Anti-Protein 1a1-3b antibody
Anti-NBR1 antibody
Anti-1A13B antibody
Anti-KIAA0049 antibody
Anti-M17S2 antibody
Anti-MIG19 antibody

Information sourced from Uniprot.org

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