| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NBR1 (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NBR1 |
| Gene ID: |
4077 |
| Uniprot ID: |
NBR1_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NBR1 (NP_005890.2). |
| Immunogen Sequence: |
MEPQVTLNVTFKNEIQSFLV SDPENTTWADIEAMVKVSFD LNTIQIKYLDEENEEVSINS QGEYEEALKMAVKQGNQLQM QVHEGHHVVDEAPPPVVGAK RLAARAGKKPLAHYSSLVRV LGSDMKTPEDPAVQSFPLVP CDTDQPQDKPPDWFTSYLET FREQVVNETVEKLEQKLHEK LVLQNPSLGSCPSEVSMPTS EETLFLPENQFSWHIACNNC QRRIVGVRYQCSLCPSYNI |
| Post Translational Modifications | (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication. Phosphorylated by GSK3A.this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates. |
| Function | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion. |
| Protein Name | Next To Brca1 Gene 1 ProteinCell Migration-Inducing Gene 19 ProteinMembrane Component Chromosome 17 Surface Marker 2Neighbor Of Brca1 Gene 1 ProteinProtein 1a1-3b |
| Database Links | Reactome: R-HSA-9664873 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleAutophagosomeLysosomeMyofibrilSarcomereM LineIn Cardiac Muscles Localizes To The Sarcomeric M LineIs Targeted To Lysosomes For Degradation |
| Alternative Antibody Names | Anti-Next To Brca1 Gene 1 Protein antibodyAnti-Cell Migration-Inducing Gene 19 Protein antibodyAnti-Membrane Component Chromosome 17 Surface Marker 2 antibodyAnti-Neighbor Of Brca1 Gene 1 Protein antibodyAnti-Protein 1a1-3b antibodyAnti-NBR1 antibodyAnti-1A13B antibodyAnti-KIAA0049 antibodyAnti-M17S2 antibodyAnti-MIG19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
