| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
NANOS2 |
| Gene ID: |
339345 |
| Uniprot ID: |
NANO2_HUMAN |
| Immunogen Region: |
1-138 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human NANOS2 (NP_001025032.1). |
| Immunogen Sequence: |
MQLPPFDMWKDYFNLSQVVW ALIASRGQRLETQEIEEPSP GPPLGQDQGLGAPGANGGLG TLCNFCKHNGESRHVYSSHQ LKTPDGVVVCPILRHYVCPV CGATGDQAHTLKYCPLNGGQ QSLYRRSGRNSAGRRVKR |
| Tissue Specificity | Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). |
| Function | Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. |
| Protein Name | Nanos Homolog 2Nos-2 |
| Cellular Localisation | CytoplasmP-BodyPerinuclear RegionLocalizes At P-Bodies During Gonocyte DevelopmentMore Abundant In Perinuclear Region Of The Cytoplasm Of The Germ Cells Of The Adult Testis |
| Alternative Antibody Names | Anti-Nanos Homolog 2 antibodyAnti-Nos-2 antibodyAnti-NANOS2 antibodyAnti-NOS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
