| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NAGS (295-534) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NAGS |
| Gene ID: |
162417 |
| Uniprot ID: |
NAGS_HUMAN |
| Immunogen Region: |
295-534 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 295-534 of human NAGS (NP_694551.1). |
| Immunogen Sequence: |
NTGGLRDSSHKVLSNVNLPA DLDLVCNAEWVSTKERQQMR LIVDVLSRLPHHSSAVITAA STLLTELFSNKGSGTLFKNA ERMLRVRSLDKLDQGRLVDL VNASFGKKLRDDYLASLRPR LHSIYVSEGYNAAAILTMEP VLGGTPYLDKFVVSSSRQGQ GSGQMLWECLRRDLQTLFWR SRVTNPINPWYFKHSDGSFS NKQWIFFWFGLADIRDSYEL VNHAKGLPDSFHKPASDPG |
| Tissue Specificity | Highly expressed in the adult liver, kidney and small intestine. Weakly expressed in the fetal liver, lung, pancreas, placenta, heart and brain tissue. |
| Post Translational Modifications | Probably processed by mitochondrial processing peptidase (MPP). The long form has not yet been isolated. |
| Function | Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. |
| Protein Name | N-Acetylglutamate Synthase - MitochondrialAmino-Acid Acetyltransferase Cleaved Into - N-Acetylglutamate Synthase Long Form - N-Acetylglutamate Synthase Short Form - N-Acetylglutamate Synthase Conserved Domain Form |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-N-Acetylglutamate Synthase - Mitochondrial antibodyAnti-Amino-Acid Acetyltransferase Cleaved Into - N-Acetylglutamate Synthase Long Form - N-Acetylglutamate Synthase Short Form - N-Acetylglutamate Synthase Conserved Domain Form antibodyAnti-NAGS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
