| Post Translational Modifications | Deubiquitinated by USP19. Isoform 4: N-glycosylated and glycosylation is required for its proper function. Isoform 3: N-glycosylated. |
| Function | NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release. Isoform 4: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in redox signaling in vascular cells. Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Isoform 3: Lacks superoxide-generating NADPH oxidase activity. |
| Protein Name | Nadph Oxidase 4Kidney Oxidase-1Kox-1Kidney Superoxide-Producing Nadph OxidaseRenal Nad(Ph-Oxidase |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-9702518Reactome: R-HSA-9703465 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembraneCell JunctionFocal AdhesionNucleusIsoform 4: NucleusNucleolusPerinuclear RegionIsoform 3: CytoplasmIsoform 5: CytoplasmIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Nadph Oxidase 4 antibodyAnti-Kidney Oxidase-1 antibodyAnti-Kox-1 antibodyAnti-Kidney Superoxide-Producing Nadph Oxidase antibodyAnti-Renal Nad(Ph-Oxidase antibodyAnti-NOX4 antibodyAnti-RENOX antibody |
Information sourced from Uniprot.org
