| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NAA50 (1-169) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NAA50 |
| Gene ID: |
80218 |
| Uniprot ID: |
NAA50_HUMAN |
| Immunogen Region: |
1-169 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-169 of human NAA50 (NP_079422.1). |
| Immunogen Sequence: |
MKGSRIELGDVTPHNIKQLK RLNQVIFPVSYNDKFYKDVL EVGELAKLAYFNDIAVGAVC CRVDHSQNQKRLYIMTLGCL APYRRLGIGTKMLNHVLNIC EKDGTFDNIYLHVQISNESA IDFYRKFGFEIIETKKNYYK RIEPADAHVLQKNLKVPSGQ NADVQKTDN |
| Function | N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity. Does not influence the acetyltransferase activity of NAA10. However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10. |
| Protein Name | N-Alpha-Acetyltransferase 50Hnaa50pN-Acetyltransferase 13N-Acetyltransferase 5Hnat5N-Acetyltransferase San HomologHsanN-Epsilon-Acetyltransferase 50Nate Catalytic Subunit |
| Cellular Localisation | CytoplasmNucleusLocalizes To The Cytoplasm In Interphase Cells |
| Alternative Antibody Names | Anti-N-Alpha-Acetyltransferase 50 antibodyAnti-Hnaa50p antibodyAnti-N-Acetyltransferase 13 antibodyAnti-N-Acetyltransferase 5 antibodyAnti-Hnat5 antibodyAnti-N-Acetyltransferase San Homolog antibodyAnti-Hsan antibodyAnti-N-Epsilon-Acetyltransferase 50 antibodyAnti-Nate Catalytic Subunit antibodyAnti-NAA50 antibodyAnti-MAK3 antibodyAnti-NAT13 antibodyAnti-NAT5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
