| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYH9 |
| Gene ID: | 4627 |
| Uniprot ID: | MYH9_HUMAN |
| Immunogen Region: | 1711-1960 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1711-1960 of human MYH9 (NP_002464.1). |
| Immunogen Sequence: | ANSSGKGALALEEKRRLEAR IAQLEEELEEEQGNTELIND RLKKANLQIDQINTDLNLER SHAQKNENARQQLERQNKEL KVKLQEMEGTVKSKYKASIT ALEAKIAQLEEQLDNETKER QAACKQVRRTEKKLKDVLLQ VDDERRNAEQYKDQADKAST RLKQLKRQLEEAEEEAQRAN ASRRKLQRELEDATETADAM NREVSSLKNKLRRGDLPFVV PRRMARKGAGDGSDEEVDG |
| Tissue Specificity | In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |
| Post Translational Modifications | ISGylated. Ubiquitination. |
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction.this function is mechanically antagonized by MYH10. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. |
| Protein Name | Myosin-9 Cellular Myosin Heavy Chain - Type A Myosin Heavy Chain 9 Myosin Heavy Chain - Non-Muscle Iia Non-Muscle Myosin Heavy Chain A Nmmhc-A Non-Muscle Myosin Heavy Chain Iia Nmmhc Ii-A Nmmhc-Iia |
| Database Links | Reactome: R-HSA-1445148 Reactome: R-HSA-2029482 Reactome: R-HSA-3928663 Reactome: R-HSA-416572 Reactome: R-HSA-5625740 Reactome: R-HSA-5625900 Reactome: R-HSA-5627117 Reactome: R-HSA-5627123 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 Reactome: R-HSA-9662834 Reactome: R-HSA-9664422 Reactome: R-HSA-9725370 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Cortex Cytoplasmic Vesicle Secretory Vesicle Cortical Granule Cell Membrane Colocalizes With Actin Filaments At Lamellipodia Margins And At The Leading Edge Of Migrating Cells In Retinal Pigment Epithelial Cells Predominantly Localized To Stress Fiber-Like Structures With Some Localization To Cytoplasmic Puncta (Microbial Infection) Localizes At The Surface Of The Cell Membrane Following Infection By Herpes Simplex Virus 1/Hhv-1 |
| Alternative Antibody Names | Anti-Myosin-9 antibody Anti-Cellular Myosin Heavy Chain - Type A antibody Anti-Myosin Heavy Chain 9 antibody Anti-Myosin Heavy Chain - Non-Muscle Iia antibody Anti-Non-Muscle Myosin Heavy Chain A antibody Anti-Nmmhc-A antibody Anti-Non-Muscle Myosin Heavy Chain Iia antibody Anti-Nmmhc Ii-A antibody Anti-Nmmhc-Iia antibody Anti-MYH9 antibody |
Information sourced from Uniprot.org