| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYH9 |
| Gene ID: | 4627 |
| Uniprot ID: | MYH9_HUMAN |
| Immunogen Region: | 1711-1960 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1711-1960 of human MYH9 (NP_002464.1). |
| Immunogen Sequence: | ANSSGKGALALEEKRRLEAR IAQLEEELEEEQGNTELIND RLKKANLQIDQINTDLNLER SHAQKNENARQQLERQNKEL KVKLQEMEGTVKSKYKASIT ALEAKIAQLEEQLDNETKER QAACKQVRRTEKKLKDVLLQ VDDERRNAEQYKDQADKAST RLKQLKRQLEEAEEEAQRAN ASRRKLQRELEDATETADAM NREVSSLKNKLRRGDLPFVV PRRMARKGAGDGSDEEVDG |
| Tissue Specificity | In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |
| Post Translational Modifications | ISGylated. Ubiquitination. |
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction.this function is mechanically antagonized by MYH10. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. |
| Protein Name | Myosin-9Cellular Myosin Heavy Chain - Type AMyosin Heavy Chain 9Myosin Heavy Chain - Non-Muscle IiaNon-Muscle Myosin Heavy Chain ANmmhc-ANon-Muscle Myosin Heavy Chain IiaNmmhc Ii-ANmmhc-Iia |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-2029482Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9662834Reactome: R-HSA-9664422Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesicleSecretory VesicleCortical GranuleCell MembraneColocalizes With Actin Filaments At Lamellipodia Margins And At The Leading Edge Of Migrating CellsIn Retinal Pigment Epithelial CellsPredominantly Localized To Stress Fiber-Like Structures With Some Localization To Cytoplasmic Puncta(Microbial Infection) Localizes At The Surface Of The Cell Membrane Following Infection By Herpes Simplex Virus 1/Hhv-1 |
| Alternative Antibody Names | Anti-Myosin-9 antibodyAnti-Cellular Myosin Heavy Chain - Type A antibodyAnti-Myosin Heavy Chain 9 antibodyAnti-Myosin Heavy Chain - Non-Muscle Iia antibodyAnti-Non-Muscle Myosin Heavy Chain A antibodyAnti-Nmmhc-A antibodyAnti-Non-Muscle Myosin Heavy Chain Iia antibodyAnti-Nmmhc Ii-A antibodyAnti-Nmmhc-Iia antibodyAnti-MYH9 antibody |
Information sourced from Uniprot.org