Anti-MYB antibody (380-640) (STJ115721)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MYB (380-640) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:10000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYB |
| Gene ID | 4602 |
| Uniprot ID | MYB_HUMAN |
| Immunogen Region | 380-640 |
| Immunogen Sequence | GTILDNVKNLLEFAETLQFI DSFLNTSSNHENSDLEMPSL TSTPLIGHKLTVTTPFHRDQ TVKTQKENTVFRTPAIKRSI LESSPRTPTPFKHALAAQEI KYGPLKMLPQTPSHLVEDLQ DVIKQESDESGIVAEFQENG PPLLKKIKQEVESPTDKSGN FFCSHHWEGDSLNTQLFTQT SPVADAPNILTSSVLMAPAS EDEDNVLKAFTVPKNRSLAS PLQPCSSTWEPASCGKMEE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 380-640 of human MYB (NP_005366.2). |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. SUMOylated by TRAF7.leading to MYB transcriptional activity inhibition. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. |
| Function | Transcriptional activator.DNA-binding protein that specifically recognize the sequence 5'-YAACGTG-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| Protein Name | Transcriptional Activator MybProto-Oncogene C-Myb |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-9616222Reactome: R-HSA-983231Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Activator Myb antibodyAnti-Proto-Oncogene C-Myb antibodyAnti-MYB antibody |
Information sourced from Uniprot.org