Anti-MX1 antibody (200-300) (STJ24650)

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STJ24650
£112.50 - £524.50
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MX1
Gene ID: 4599
Uniprot ID: MX1_HUMAN
Immunogen Region: 200-300
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human MX1 (NP_001171517.1).
Immunogen Sequence: TLIKKYIQRQETISLVVVPS NVDIATTEALSMAQEVDPEG DRTIGILTKPDLVDKGTEDK VVDVVRNLVFHLKKGYMIVK CRGQQEIQDQLSLSEALQRE K
Post Translational Modifications ISGylated.
Function Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
Protein Name Interferon-Induced Gtp-Binding Protein Mx1
Interferon-Induced Protein P78
Ifi-78k
Interferon-Regulated Resistance Gtp-Binding Protein Mxa
Myxoma Resistance Protein 1
Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Perinuclear Region
Binds Preferentially To Negatively Charged Phospholipids
Colocalizes With Cchfv Protein N In The Perinuclear Region
Isoform 2: Cytoplasm
Nucleus
Translocates Into The Nuclei Of Hsv-1 Infected Cells
Alternative Antibody Names Anti-Interferon-Induced Gtp-Binding Protein Mx1 antibody
Anti-Interferon-Induced Protein P78 antibody
Anti-Ifi-78k antibody
Anti-Interferon-Regulated Resistance Gtp-Binding Protein Mxa antibody
Anti-Myxoma Resistance Protein 1 antibody
Anti-Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed antibody
Anti-MX1 antibody

Information sourced from Uniprot.org