| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MVD |
| Gene ID: | 4597 |
| Uniprot ID: | MVD1_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MVD (NP_002452.1). |
| Immunogen Sequence: | MASEKPLAAVTCTAPVNIAV IKYWGKRDEELVLPINSSLS VTLHQDQLKTTTTAVISKDF TEDRIWLNGREEDVGQPRLQ ACLREIRCLARKRRNSRDGD PLPSSLSCKVHVASVNNFPT AAGLASSAAGYACLAYTLAR VYGVESDLSEVARRGSGSAC RSLYGGFVEWQMGEQADGKD SIARQVAPESHWPELRVLIL VVSAEKKLTGSTVGMRASVE TSPLLRFRAESVVPARMAE |
| Tissue Specificity | Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta. |
| Function | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. |
| Protein Name | Diphosphomevalonate DecarboxylaseMevalonateDiphosphodecarboxylaseMddaseMevalonate Pyrophosphate Decarboxylase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168Reactome: R-HSA-446199 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Diphosphomevalonate Decarboxylase antibodyAnti-Mevalonate antibodyAnti-Diphosphodecarboxylase antibodyAnti-Mddase antibodyAnti-Mevalonate Pyrophosphate Decarboxylase antibodyAnti-MVD antibodyAnti-MPD antibody |
Information sourced from Uniprot.org