Anti-Muscarinic Acetylcholine Receptor M2 antibody [R06-6R2] (STJA0037248)

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STJA0037248
€160.20 - €337.80
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Host: Rabbit
Applications: WB/IHC-P/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Muscarinic Acetylcholine Receptor M2 for use in WB, IHC-P and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R06-6R2
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IP 1:50
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: CHRM2
Gene ID: 1129
Uniprot ID: ACM2_HUMAN
Immunogen: A synthesized peptide derived from human ACM2
Post Translational Modifications Phosphorylated in response to agonist treatment.
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol.
Protein Name Muscarinic Acetylcholine Receptor M2
Database Links Reactome: R-HSA-390648
Reactome: R-HSA-418594
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Phosphorylation In Response To Agonist Binding Promotes Receptor Internalization
Alternative Antibody Names Anti-Muscarinic Acetylcholine Receptor M2 antibody
Anti-CHRM2 antibody

Information sourced from Uniprot.org

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