| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MURF1/TRIM63 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-1.25µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TRIM63 |
| Gene ID: |
84676 |
| Uniprot ID: |
TRI63_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_115977.2 |
| Immunogen Sequence: |
QQYQEQLDKSTKLVE |
| Function | E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim63Iris Ring Finger ProteinMuscle-Specific Ring Finger Protein 1Murf-1Murf1Ring Finger Protein 28Ring-Type E3 Ubiquitin Transferase Trim63Striated Muscle Ring Zinc Finger ProteinTripartite Motif-Containing Protein 63 |
| Database Links | Reactome: R-HSA-9615017Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomereM LineZ LineColocalizes With Tnni3 In MyocytesLocalizes To The M- And Z-Lines In Skeletal Muscle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim63 antibodyAnti-Iris Ring Finger Protein antibodyAnti-Muscle-Specific Ring Finger Protein 1 antibodyAnti-Murf-1 antibodyAnti-Murf1 antibodyAnti-Ring Finger Protein 28 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim63 antibodyAnti-Striated Muscle Ring Zinc Finger Protein antibodyAnti-Tripartite Motif-Containing Protein 63 antibodyAnti-TRIM63 antibodyAnti-IRF antibodyAnti-MURF1 antibodyAnti-RNF28 antibodyAnti-SMRZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
