Anti-Mucolipin 2 antibody (STJ13100251)

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STJ13100251-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Mucolipin 2 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Mcoln2
Gene ID: 68279
Uniprot ID: MCLN2_MOUSE
Specificity: Specific for Mucolipin 2.
Immunogen: A synthetic peptide from mouse Mucolipin 2 conjugated to blue carrier protein was used as the antigen.
Function Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel.
Protein Name Mucolipin-2
Transient Receptor Potential Channel Mucolipin 2
Trpml2
Database Links Reactome: R-MMU-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Recycling Endosome Membrane
Localizes To Recycling Endosomes In Activated Macrophages And Microglia
Alternative Antibody Names Anti-Mucolipin-2 antibody
Anti-Transient Receptor Potential Channel Mucolipin 2 antibody
Anti-Trpml2 antibody
Anti-Mcoln2 antibody

Information sourced from Uniprot.org

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