• Anti-MUC5AC/M1 antibody [58M1] (STJ16100710)

Anti-MUC5AC/M1 antibody [58M1] (STJ16100710)

SKU:
STJ16100710

£264.50 - £1,251.50
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Host: Mouse
Applications: ELISA/WB/IHC
Reactivity: Cat/Cow/Human/Monkey/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MUC5AC/M1 is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 58M1
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Immunoblotting (1-2 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: MUC5AC
Gene ID: 4586
Uniprot ID: MUC5A_HUMAN
Immunogen: A BALB/c mouse was immunized with mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification) from an ALeb patient. Fusion partner: SP2/0.
Tissue Specificity Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.
Post Translational Modifications C-, O- and N-glycosylated. O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA. One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached. It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
Function Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).
Protein Name Mucin-5ac
Muc-5ac
Gastric Mucin
Major Airway Glycoprotein
Mucin-5 Subtype Ac - Tracheobronchial
Tracheobronchial Mucin
Tbm
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Secreted
Alternative Antibody Names Anti-Mucin-5ac antibody
Anti-Muc-5ac antibody
Anti-Gastric Mucin antibody
Anti-Major Airway Glycoprotein antibody
Anti-Mucin-5 Subtype Ac - Tracheobronchial antibody
Anti-Tracheobronchial Mucin antibody
Anti-Tbm antibody
Anti-MUC5AC antibody
Anti-MUC5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance